Electrostatic charge effects on aerosol deposition in a multiscale in vitro one-path lung model
Ron Bessler, Tirosh Mekler, Daniel Malka, Nadia Onallah, Oshri Farhana, Rami Fishler, Saurabh Bhardwaj, Kenichiro Koshiyama, Netanel Korin, and Josué Sznitman
Phys. Rev. Fluids 11, 050501 (2026) - Published 18 May, 2026
Existing studies of charged aerosol deposition have largely focused on isolated upper-airway or local truncated in vitro models, leaving whole-lung scale effects unresolved. Using a physiologically inspired multiscale airway-on-chip spanning conducting to acinar regions, we investigated the electrostatic contributions along with gravity, impaction, and diffusion. Our results show that charge significantly reshapes deposition patterns, enhancing early bronchiolar capture while reducing delivery to the distal acinus.
























































