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Orientational correlations in confined DNA

E. Werner1,*, F. Persson1,*, F. Westerlund2, J. O. Tegenfeldt1,3, and B. Mehlig1

  • 1Department of Physics, University of Gothenburg, Sweden
  • 2Department of Chemical and Biological Engineering, Chalmers University of Technology, Sweden
  • 3Department of Physics, Division of Solid State Physics, Lund University

  • *E. Werner and F. Persson contributed equally to this work.
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Phys. Rev. E 86, 041802 – Published 11 October, 2012

DOI: https://doi.org/10.1103/PhysRevE.86.041802

Abstract

We study how the orientational correlations of DNA confined to nanochannels depend on the channel diameter D by means of Monte Carlo simulations and a mean-field theory. This theory describes DNA conformations in the experimentally relevant regime where the Flory–de Gennes theory does not apply. We show how local correlations determine the dependence of the end-to-end distance of the DNA molecule upon D. Tapered nanochannels provide the necessary resolution in D to study experimentally how the extension of confined DNA molecules depends upon D. Our experimental and theoretical results are in qualitative agreement.

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Outline

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Phys. Rev. E 86, 041802– Published 11 October, 2012
  • Received 16 January 2012

©2012 American Physical Society

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