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HIGHLIGHTED ARTICLES

RNA-induced Allosteric Coupling Drives Viral Capsid Assembly

Sean Hamilton, Tushar Modi, Petr Šulc, and S. Banu Ozkan

PRX Life 2, 013012 (2024) - Published 12 March, 2024

In this study, RNA-mediated allosteric protein regulation is proposed as a key mechanism driving viral capsid formation, revealing how single mutations can disrupt viral assembly and identifying new targets for antiviral treatments.

Interactions and Migration Rescuing Ecological Diversity

Giulia Garcia Lorenzana, Ada Altieri, and Giulio Biroli

PRX Life 2, 013014 (2024) - Published 18 March, 2024

In this study, the authors describe the phase diagram of an ecological system with demographic noise, heterogeneous interactions, and migration, showing how mutualism can spontaneously emerge.

ARTICLES

Phenotypic Variability Shapes Bacterial Responses to Opposing Gradients

Lusi Li, Xuanqi Zhang, Yanhong Sun, Qi Ouyang, Yuhai Tu, and Chunxiong Luo

PRX Life 2, 013001 (2024) - Published 9 January, 2024

In study the authors show how the balance of two chemoreceptors and the strength of opposing gradients unlocks the prediction of bacterial adaptive responses to complex environments.

Mechanisms of Sarcomere Assembly in Muscle Cells Inferred from Sequential Ordering of Myofibril Components

Francine Kolley, Clara Sidor, Benoit Dehapiot, Frank Schnorrer, and Benjamin M. Friedrich

PRX Life 2, 013002 (2024) - Published 11 January, 2024

In this study, the authors propose mechanisms for how sarcomeres - the regular contractile units in muscle cells - self-assemble based on data indicating that myosin motors and actin crosslinkers initially form periodic patterns.

Measuring Vibrational Modes in Living Human Cells

Verónica Puerto-Belda, Jose J. Ruz, Carmen Millá, Álvaro Cano, Marina L. Yubero, Sergio García, Priscila M. Kosaka, Montserrat Calleja, and Javier Tamayo

PRX Life 2, 013003 (2024) - Published 18 January, 2024

In this study, the authors measure vibration modes in human living cells, solving a 70-year-old mystery, using advanced microcantilever technology, which has potential application in cell fingerprinting and cell killing by ultrasound waves.

Elastic Contractile Stress in the Basement Membrane Generates Basal Tension in Epithelia

K. Yanín Guerra Santillán, Christian Dahmann, and Elisabeth Fischer-Friedrich

PRX Life 2, 013004 (2024) - Published 23 January, 2024

In this study, the authors employ atomic force microscopy to reveal how cells exert active forces on the basement membrane, measuring the tensions that shape and sustain the architecture of epithelial tissues.

Impact of Isotopic Exchange on Hydrated Protein Dynamics Revealed by Polarized Neutron Scattering

Agathe Nidriche, Martine Moulin, Philippe Oger, J. Ross Stewart, Lucile Mangin-Thro, Wolfgang Schmidt, Gerald Kneller, and Judith Peters

PRX Life 2, 013005 (2024) - Published 25 January, 2024

In this study, the authors show that the collective motions of deuterium-enriched water can affect the protein dynamics in hydrated powders, posing a challenge to conventional deuteration techniques in neutron scattering studies.

Four-Dimensional Mesoscale Liquid Model of Nucleus Resolves Chromatin's Radial Organization

Rabia Laghmach, Michele Di Pierro, and Davit A. Potoyan

PRX Life 2, 013006 (2024) - Published 30 January, 2024

In this study, the authors introduce MELON-4D, a computational tool for modeling chromatin organization in four dimensions. Initially applied to the Drosophila nucleus, its versatility allows it to reveal the underlying forces shaping nuclear architecture and dynamics across eukaryotes.

Ion Channels in Critical Membranes: Clustering, Cooperativity, and Memory Effects

Antonio Suma, Daniel Sigg, Seamus Gallagher, Giuseppe Gonnella, and Vincenzo Carnevale

PRX Life 2, 013007 (2024) - Published 8 February, 2024

This study proposes a unifying explanation for ion channels collective behaviors such as clustering, cooperativity, and memory effects through lipid-mediated interactions.

Geometrical Structure of Bifurcations during Spatial Decision-Making

Dan Gorbonos, Nir S. Gov, and Iain D. Couzin

PRX Life 2, 013008 (2024) - Published 13 February, 2024

In the study, authors reveal new geometric principles of bifurcations during spatiotemporal decision-making and demonstrate that a non-Euclidean neural representation of space simplifies decision-making in multi-target environments.

Single-Molecule Morphology of Topologically Digested Olympic Networks

Saminathan Ramakrishnan, Zihao Chen, Yair Augusto Gutierrez Fosado, Luca Tubiana, Willem Vanderlinden, Nicholas Jon Savill, Achim Schnaufer, and Davide Michieletto

PRX Life 2, 013009 (2024) - Published 20 February, 2024

Using Atomic Force Microscopy and targeted enzymatic digestion, this study untangles the knots of the kinetoplast DNA, a unique genome made of interlinked DNA rings found in parasites, and uncovers the organisation of this unique structure.

Gene Expression Tradeoffs Determine Bacterial Survival and Adaptation to Antibiotic Stress

Josiah C. Kratz and Shiladitya Banerjee

PRX Life 2, 013010 (2024) - Published 29 February, 2024

In this study, the authors present a theory connecting environmental conditions with intracellular events, which explains why stressed cells are more resilient to future stress.

Local and Global Variability in Developing Human T-Cell Repertoires

Giulio Isacchini, Valentin Quiniou, Pierre Barennes, Vanessa Mhanna, Hélène Vantomme, Paul Stys, Encarnita Mariotti-Ferrandiz, David Klatzmann, Aleksandra M. Walczak, Thierry Mora, and Armita Nourmohammad

PRX Life 2, 013011 (2024) - Published 8 March, 2024

By studying the effect of thymic selection on the variability of the human T-cell receptor beta chain repertoire, the authors of this work found a smooth landscape challenging the concept of ‘forbidden’ receptors.

RNA-induced Allosteric Coupling Drives Viral Capsid Assembly

Sean Hamilton, Tushar Modi, Petr Šulc, and S. Banu Ozkan

PRX Life 2, 013012 (2024) - Published 12 March, 2024

In this study, RNA-mediated allosteric protein regulation is proposed as a key mechanism driving viral capsid formation, revealing how single mutations can disrupt viral assembly and identifying new targets for antiviral treatments.

Effect of Synaptic Heterogeneity on Neuronal Coordination

Moritz Layer, Moritz Helias, and David Dahmen

PRX Life 2, 013013 (2024) - Published 14 March, 2024

In this study, the authors explain how the variability in connection patterns among neurons influences the heterogeneity found in neuron activity.

Interactions and Migration Rescuing Ecological Diversity

Giulia Garcia Lorenzana, Ada Altieri, and Giulio Biroli

PRX Life 2, 013014 (2024) - Published 18 March, 2024

In this study, the authors describe the phase diagram of an ecological system with demographic noise, heterogeneous interactions, and migration, showing how mutualism can spontaneously emerge.

Emergence of Homochirality via Template-Directed Ligation in an RNA Reactor

Gabin Laurent, Tobias Göppel, David Lacoste, and Ulrich Gerland

PRX Life 2, 013015 (2024) - Published 22 March, 2024

In this study, the authors show how template-directed RNA ligation under non-equilibrium conditions could spontaneously lead to homochirality, offering insights on the origin of life.

Finding the Last Bits of Positional Information

Lauren McGough, Helena Casademunt, Miloš Nikolić, Zoe Aridor, Mariela D. Petkova, Thomas Gregor, and William Bialek

PRX Life 2, 013016 (2024) - Published 26 March, 2024

This study shows that spatial correlations add to the information that cells can derive about their position in the embryo, and experimental data shows that this extra information is just enough to specify cellular identities uniquely.

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