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Dynamics of bubbles and ultrasound: Diagnostic imaging to blood pressure monitoring and tissue engineering

Kausik Sarkar

  • Contact author: sarkar@gwu.edu
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Phys. Rev. Fluids 10, 030501 – Published 17 March, 2025

DOI: https://doi.org/10.1103/PhysRevFluids.10.030501

Abstract

Coated microbubbles in conjunction with ultrasound have emerged as an important biomedical tool for diagnostic imaging and therapeutics. Here, I offer my perspective based on research spanning over two decades, highlighting the underlying physics of linear and nonlinear bubble dynamics. I will describe our effort at mathematical modeling of contrast microbubble behaviors, specifically our adoption of an interfacial rheological model for the stabilizing shell and a hierarchical approach of model building and improvement using attenuation and scattering experiments. I will describe our collaborative effort at using the sensitivity of the acoustic response of microbubbles to ambient hydrostatic pressure for a subharmonic aided pressure estimation (SHAPE) method for noninvasive organ-level blood pressure monitoring. Other collaborative projects demonstrated microbubbles together with low-intensity pulsed ultrasound (LIPUS) to be an effective tool in tissue engineering, growing bone and cartilage from human mesenchymal stem cells in a 3D printed tissue engineering scaffold. We have theoretically investigated various underlying mechanisms for such bioeffects of ultrasound-insonated microbubbles, specifically microstreaming at low acoustic excitations and cavitating jet formation at high excitations for shelled microbubbles. Finally, I briefly describe my computational research on viscous and viscoelastic emulsions and suspensions of drops, vesicles, and biological cells.

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Phys. Rev. Fluids 10, 030501– Published 17 March, 2025
  • Received 22 July 2024
  • Accepted 21 October 2024
Article part of CHORUS
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