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Neural field theory of effects of brain modifications and lesions on functional connectivity: Acute effects, short-term homeostasis, and long-term plasticity

P. A. Robinson

  • School of Physics, University of Sydney, New South Wales 2006, Australia and Center for Integrative Brain Function, University of Sydney, New South Wales 2006, Australia

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Phys. Rev. E 99, 042407 – Published 18 April, 2019

DOI: https://doi.org/10.1103/PhysRevE.99.042407

Abstract

Neural field theory is used to predict the functional connectivity effects of lesions or other modifications to effective connectivity. Widespread initial changes are predicted after localized or diffuse changes to white or gray matter, consistent with observations, and enabling lesion severity indexes to be defined. It is shown how short-term homeostasis and longer-term plasticity can reduce perturbations while maintaining brain criticality under conditions where some connections remain fixed because of damage in the lesion core. The extent to which such effects can compensate for initial connectivity changes is then explored, showing that the strongest corrective changes are concentrated toward the edges of the perturbation if it is localized and its core is fixed. The results are applicable to inferring underlying connectivity changes and to interpreting and monitoring functional connectivity modifications after lesions, injury, surgery, drugs, or brain stimulation.

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Outline

Information

Phys. Rev. E 99, 042407– Published 18 April, 2019
  • Received 6 April 2018
  • Revised 27 July 2018
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