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Entrainment range of the suprachiasmatic nucleus affected by the difference in the neuronal amplitudes between the light-sensitive and light-insensitive regions

Changgui Gu1,*, Huijie Yang1, and Zhongyuan Ruan2

  • 1Business School, University of Shanghai for Science and Technology, Shanghai 200093, People's Republic of China
  • 2College of Computer Science, Zhejiang University of Technology, Hangzhou 310023, People's Republic of China

  • *Corresponding author: gu_changgui@163.com
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Phys. Rev. E 95, 042409 – Published 25 April, 2017

DOI: https://doi.org/10.1103/PhysRevE.95.042409

Abstract

Mammals not only can be synchronized to the natural 24-h light-dark cycle, but also to a cycle with a non-24-h period. The range of the period of the external cycle, for which the animals can be entrained to, is called the entrainment range, which differs among species. The entrainment range as a characteristic of the animal is determined by the main circadian clock, i.e., the suprachiasmatic nucleus (SCN) in the brain. The SCN is composed of ∼10000 heterogeneous neurons, which can be divided into two subgroups, i.e., the ventrolateral subgroup (VL) directly receiving the light information from the retina and relaying the information to the dorsomedial subgroup (DM). Among the SCN neurons, the amplitudes are different; however, it is unclear that the amplitude is related to the location of the neurons in experiments. In the present study, we examined the effect of the difference in the neuronal amplitude between the VL and the DM on the entrainment range of the SCN, based on a mathematical model, i.e., the Poincaré model, which is used to describe the circadian clock. We find that the maximal entrainment range is obtained when the difference is equal to a critical point. If the difference of the amplitudes of the VL neurons to the amplitudes of the DM neurons is smaller than a critical point, with the increase of the difference, the entrainment range of the SCN increases, while if the difference is larger than the critical point, the entrainment range decreases with the increase of the difference. Our finding may give a potential explanation for the diversity of the entrainment range among species.

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Phys. Rev. E 95, 042409– Published 25 April, 2017
  • Received 25 February 2017

©2017 American Physical Society

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