- Physical Review Journals
All JournalsPhysics Magazine
Access Provided by Xinjiang University

Physical Review E

Export citation

Export citation

Choose format for download:

Download Citation
  • Access by Xinjiang University

Kinetics of virus entry by endocytosis

Vladimir P. Zhdanov*

  • Department of Applied Physics, Chalmers University of Technology, S-41296 Göteborg, Sweden and Boreskov Institute of Catalysis, Russian Academy of Sciences, Novosibirsk 630090, Russia

  • *zhdanov@catalysis.ru
PDF

Phys. Rev. E 91, 042715 – Published 28 April, 2015

DOI: https://doi.org/10.1103/PhysRevE.91.042715

Abstract

Entry of virions into the host cells is either endocytotic or fusogenic. In both cases, it occurs via reversible formation of numerous relatively weak bonds resulting in wrapping of a virion by the host membrane with subsequent membrane rupture or scission. The corresponding kinetic models are customarily focused on the formation of bonds and do not pay attention to the energetics of the whole process, which is crucially dependent, especially in the case of endocytosis, on deformation of actin filaments forming the cytoskeleton of the host cell. The kinetic model of endocytosis, proposed by the author, takes this factor into account and shows that the whole process can be divided into a rapid initial transient stage and a long steady-state stage. The entry occurs during the latter stage and can be described as a first-order reaction. Depending on the details of the dependence of the grand canonical potential on the number of bonds, the entry can be limited either by the interplay of bond formation and membrane rupture (or scission) or by reaching a maximum of this potential.

View figure in article

Article Text

References (30)

  1. A. J. Cann, Principles of Molecular Virology (Elsevier, Amsterdam, 2012).
  2. J. Mercer, M. Schelhaas, and A. Helenius, Ann. Rev. Biochem. 79, 803 (2010).
  3. Y. Sidorenko, A. Voigt, J. Schulze-Horsel, U. Reichl, and A. Kienle, Chem. Eng. Sci. 63, 2299 (2008); J. Sardanyes and S. F. Elena, PLoS ONE 6, e24884 (2011).
  4. M. Bally, K. Dimitrievski, G. Larson, V. P. Zhdanov, and F. Höök, Phys. Biol. 9, 026011 (2012).
  5. R. Zandi, P. van der Schoot, D. Reguera, W. Kege, and H. Reiss, Biophys. J. 90, 1939 (2006); A. Yu. Morozov, R. F. Bruinsma, and J. Rudnick, J. Chem. Phys. 131, 155101 (2009); A. Zlotnick, J. Z. Porterfield, and J. C.-Y. Wang, Biophys. J. 104, 1595 (2013); M. Castelnovo, T. Verdier, and L. Foret, Eur. Phys. Lett. 105, 28006 (2014); E. C. Dykeman, P. G. Stockley, and R. Twarock, Proc. Natl. Acad. Sci. USA 111, 5361 (2014); V. P. Zhdanov, Phys. Rev. E 90, 042721 (2014).
  6. M. G. Mateu, Arch. Biochem. Biophys. 531, 65 (2013).
  7. E. Barrow, A. V. Nicola, and J. Liu, Virology J. 10, 177 (2013).
  8. Y. Yamauchi and A. Helenius, J. Cell. Sci. 126, 1289 (2013).
  9. I. Canton and G. Battaglia, Chem. Soc. Rev. 41, 2718 (2012).
  10. H. M. van der Schaar, M. J. Rust, C. Chen, H. van der Ende-Metselaar, J. Wilschut, X. Zhuang, and J. M. Smit, PLoS Path. 4, e1000244 (2008); D. Sivaraman, P. Biswas, L. N. Cella, M. V. Yates, and W. Chen, Trends Biotechnol. 29, 307 (2011); M. Bally, A. Gunnarsson, L. Svensson, G. Larson, V. P. Zhdanov, and F. Höök, Phys. Rev. Lett. 107, 188103 (2011).
  11. A. Handel, V. Akin, S. S. Pilyugin, V. Zarnitsyna, and R. Antia, J. R. Soc. Interf. 11, 20131083 (2014).
  12. T. J. English and D. A. Hammer, Biophys. J. 86, 3359 (2004); 88, 1666 (2005); T. Chou and M. R. D'Orsogna, J. Chem. Phys. 127, 105101 (2007); O. M. Szklarczyk, N. Gonzalez-Segredo, P. Kukura, A. Oppenheim, D. Choquet, V. Sandoghdar, A. Helenius, I. F. Sbalzarini, and H. Ewers, PLoS Comput. Biol. 9, e1003310 (2013).
  13. T. Chou, Biophys. J. 93, 1116 (2007); S. A. Nowak and T. Chou, ibid. 96, 2624 (2009).
  14. M. M. Gibbons, T. Chou, and M. R. D'Orsogna, J. Phys. Chem. B 114, 15403 (2010).
  15. S. A. Nowak and T. Chou, Phys. Rev. E 78, 021908 (2008).
  16. V. P. Zhdanov, Cent. Eur. J. Phys. 10, 1210 (2012).
  17. S. X. Sun and D. Wirtz, Biophys. J. 90, L10 (2006); A. Gefen, J. Biomech. Eng. 132, 084501 (2010); L. Li, X. Liu, Y. Zhou, and J. Wang, Biophys. J. 102, 2230 (2012).
  18. V. P. Zhdanov, Phys. Rev. E 88, 064701 (2013).
  19. P. Decuzzi and M. Ferrari, Biophys. J. 94, 3790 (2008); R. Vacha, F. J. Martinez-Veracoechea, and D. Frenkel, Nano Lett. 11, 5391 (2011); S. Dasgupta, T. Auth, and G. Gompper, Soft Matter 9, 5473 (2013); M. Raatz, R. Lipowsky, and T. R. Weikl, ibid. 10, 3570 (2014); A. H. Bahrami, M. Raatz, J. Agudo-Canalejo, R. Michel, E. M. Curtis, C. K. Hall, M. Gradzielski, R. Lipowsky, and T. R. Weikl, Adv. Coll. Interf. Sci. 208, 214 (2014).
  20. V. P. Zhdanov, Elementary Physicochemical Processes on Solid Surfaces (Plenum, New York, 1991).
  21. J. A. Jackman, G. H. Zan, V. P. Zhdanov, and N.-J. Cho, J. Phys. Chem. B 117, 16117 (2013).
  22. V. P. Zhdanov and B. Kasemo, Langmuir 17, 3518 (2001).
  23. B. Antonny, Ann. Rev. Biochem. 80, 101 (2011); T. Baumgart, B. R. Capraro, C. Zhu, and S. L. Das, Annu. Rev. Phys. Chem. 62, 483 (2011); V. P. Zhdanov and F. Höök, Biophys. Chem. 170, 17 (2012); A. Tonnesen, S. M. Christensen, V. Tkach, and D. Stamou, Biophys. J. 106, 201 (2014); M. Rabe, S. R. Tabaei, H. Zetterberg, V. P. Zhdanov, and F. Höök, Angew. Chem. Int. Ed. 54, 1022 (2015).
  24. F. Huber, J. Schnaus, S. Rönicke, P. Rauch, K. Müller, C. Fütterer, and J. Käs, Advances Phys. 62, 1 (2013).
  25. M. F. Coughlin and D. Stamenović, Biophys. J. 84, 1328 (2003); D. A. Head, A. J. Levine, and F. C. MacKintosh, Phys. Rev. E. 68, 061907 (2003); S. Roy and H. J. Qi, Phys. Rev. E 77, 061916 (2008); X. M. Mao, O. Stenull, and T. C. Lubensky, Phys. Rev. E. 87, 042602 (2013).
  26. T.-J. Chen, C.-C. Wu, and F.-C. Su, Med. Engin. Phys. 34, 1375 (2012).
  27. M. Dhamala, V. K. Jirsa, and M. Ding, Phys. Rev. Lett. 92, 028101 (2004).
  28. H. A. Kramers, Physica 7, 284 (1940).
  29. E. E. Nikitin, Theory of Elementary Atomic and Molecular Processes in Gases (Clarendon, Oxford, 1974); P. Hänggi, P. Talkner, and M. Borkovec, Rev. Mod. Phys. 62, 251 (1990).
  30. M. E. Breimer, G. C. Hansson, K.-A. Karlsson, G. Larson, and H. Leffler, Glycobiol. 22, 1721 (2012).

Outline

Information

Phys. Rev. E 91, 042715– Published 28 April, 2015
  • Received 20 December 2014

©2015 American Physical Society

Sign In to Your Journals Account

Filter

Filter

Article Lookup

Enter a citation