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Focusing in multiwell potentials: Applications to ion channels

L. Ponzoni1, G. L. Celardo2, F. Borgonovi2, L. Kaplan3, and A. Kargol4

  • 1Dipartimento di Matematica e Fisica, Università Cattolica, via Musei 41, 25121 Brescia, Italy
  • 2Dipartimento di Matematica e Fisica and Interdisciplinary Laboratories for Advanced Materials Physics, Università Cattolica, via Musei 41, 25121 Brescia, Italy and INFN, Sezione di Pavia, 27100 Pavia, Italy
  • 3Department of Physics, Tulane University, New Orleans, Louisiana 70118, USA
  • 4Department of Physics, Loyola University, New Orleans, Louisiana 70118, USA

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Phys. Rev. E 87, 052137 – Published 28 May, 2013

DOI: https://doi.org/10.1103/PhysRevE.87.052137

Abstract

We investigate nonequilibrium stationary distributions induced by stochastic dichotomous noise in double-well and multiwell models of ion channel gating kinetics. The channel kinetics is analyzed using both overdamped Langevin equations and master equations. With the Langevin equation approach we show a nontrivial focusing effect due to the external stochastic noise, namely, the concentration of the probability distribution in one of the two wells of a double-well system or in one or more of the wells of the multiwell model. In the multiwell system, focusing in the outer wells is shown to be achievable under physiological conditions, while focusing in the central wells has proved possible so far only at very low temperatures. We also discuss the strength of the focusing effect and obtain the conditions necessary for maximal focusing to appear. These conditions cannot be predicted by a simple master equation approach.

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Phys. Rev. E 87, 052137– Published 28 May, 2013
  • Received 28 February 2013
Article part of CHORUS

©2013 American Physical Society

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