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Metrics for characterizing collective transport by multiple dimeric kinesins

Woochul Nam* and Bogdan I. Epureanu†

  • Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA

  • *wcnam@umich.edu
  • †Corresponding author: epureanu@umich.edu
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Phys. Rev. E 86, 051916 – Published 29 November, 2012

DOI: https://doi.org/10.1103/PhysRevE.86.051916

Abstract

Kinesin is a processive molecular motor which transports various cellular cargos by converting chemical energy into mechanical movements. Although the motion of a single molecule has been characterized in several studies, the dynamics of collective transport remains controversial. Since the chemical reactions fueling molecular motors are stochastic processes, the movements of coupled motors are not perfectly synchronized. The goal of this study is to develop metrics to analyze the level of synchronization of coupled (stochastic) motors. The correlation among movements of coupled motors, the slackness, the cooperativity, and the power loss of kinesins are explored using the developed metrics. These metrics can be extended to characterize collective work done by other molecular motors also.

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Corrections

14 October, 2013

Erratum

Publisher's Note: Metrics for characterizing collective transport by multiple dimeric kinesins [Phys. Rev. E 86, 051916 (2012)]

Woochul Nam and Bogdan I. Epureanu
Phys. Rev. E 88, 049902 (2013)

Article Text

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Outline

Information

Phys. Rev. E 86, 051916– Published 29 November, 2012
  • Received 11 April 2012
  • Corrected 14 October 2013

©2012 American Physical Society

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