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Dynamic regulation on energy landscape evolution of single-molecule protein by conformational fluctuation

Chien Y. Lin and Jung Y. Huang*

Leu-Wei Lo

  • Department of Photonics and Institute of Electro-Optical Engineering, Chiao Tung University, Hsinchu 300, Taiwan, Republic of China

  • Division of Medical Engineering Research, National Health Research Institutes, Zhunan, Miaoli 350, Taiwan, Republic of China

  • *jyhuang@faculty.nctu.edu.tw
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Phys. Rev. E 86, 021925 – Published 31 August, 2012

DOI: https://doi.org/10.1103/PhysRevE.86.021925

Abstract

We formalize a theory to help explore the effect of conformational fluctuation on the energy landscape evolution of single-molecule protein. Using this formalization, we investigate the photon emission from single photoactivated fluorescent protein. A bimodal regulation on the energy landscape evolution was discovered, and its origin was attributed to slow conformational fluctuations of the protein matrix.

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Phys. Rev. E 86, 021925– Published 31 August, 2012
  • Received 4 June 2012

©2012 American Physical Society

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