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Role of the electrostatic depletion attraction on the structure of charged liposome-polymer mixtures

M. Peláez-Fernández1, A. Moncho-Jordá1, S. García-Jimeno2, J. Estelrich2, and J. Callejas-Fernández1

  • 1Grupo de Física de Fluidos y Biocoloides, Departamento de Física Aplicada, Facultad de Ciencias, Universidad de Granada, E-18071 Granada, Spain
  • 2Departament de Fisicoquímica, Facultat de Farmàcia, Universitat de Barcelona, E-08028 Barcelona, Catalonia, Spain

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Phys. Rev. E 85, 051405 – Published 29 May, 2012

DOI: https://doi.org/10.1103/PhysRevE.85.051405

Abstract

The effect of adding charged nonadsorbing polymers to electrostatically structured suspensions of charged liposomes has been experimentally studied by means of light scattering techniques. The static structure factor of the mixtures is analyzed using two polymers of different sizes. As the polymer concentration increases, the main peak of the structure factor decreases and shows an important shift to larger values of the scattering vector. Such displacement is the consequence of the electrostatic-enhanced depletion attraction induced by the polymers that counteracts the electrostatic repulsion. For the shorter polymer, the system remains stable for all studied polymer concentrations. However, for the long polymer chains, the effective attraction induced at the highest polymer density studied is strong enough to destabilize the mixture. In this case, the aggregation of the liposomes leads to clusters of nearly linear morphology. The PRISM theory is employed to calculate the effective pair potential between liposomes. The theoretical predictions are able to support the experimental observations, and provide an explanation of the interplay between the electrostatic repulsive interaction and the depletion attraction. In particular, they show that the depletion attraction is especially long ranged, and is dominated by electrostatic effects rather than entropic.

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Phys. Rev. E 85, 051405– Published 29 May, 2012
  • Received 26 July 2011

©2012 American Physical Society

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