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Predicting the entrainment of reentrant cardiac waves using phase resetting curves

Leon Glass1, Yoshihiko Nagai1, Kevin Hall2, Mario Talajic3, and Stanley Nattel3

  • 1Centre for Nonlinear Dynamics and Department of Physiology, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec, Canada H3G 1Y6
  • 2Entelos Inc., 4040 Campbell Avenue, Suite 200, Menlo Park, California 94040
  • 3Montreal Heart Institute, Montreal, Quebec, Canada H1T 1C8

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Phys. Rev. E 65, 021908 – Published 24 January, 2002

DOI: https://doi.org/10.1103/PhysRevE.65.021908

Abstract

Excitable media, such as the Belousov-Zhabotinsky medium or the heart, are capable of supporting excitation waves that circulate in a closed repetitive path—a phenomenon known as reentrant excitation. A single stimulus, depending on its magnitude, timing, and location, can cause a time shift of the reentrant excitation called resetting. The present study examines the ability of resetting data to predict the effects of periodic stimuli on reentrant excitation circulating on an annular domain. We compare the results of the theoretical models with experiments carried out in an animal model of a dangerous reentrant cardiac rhythm. The current work may lead to improved approaches to therapy through a better understanding of how typical clinical stimuli interact with abnormal reentrant cardiac rhythms.

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Phys. Rev. E 65, 021908– Published 24 January, 2002
  • Received 14 June 2001

© 2002 American Physical Society

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