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Vibrational dynamics of wet-spun films of the NaDNA-netropsin complex: A Raman and infrared study

S. A. Lee

B. Sclavi and J. W. Powell

W. Williamson, III

A. Rupprecht

  • Department of Physics and Astronomy, University of Toledo, Toledo, Ohio 43606

  • Department of Physics, Reed College, Portland, Oregon 97202

  • Department of Physics and Astronomy, University of Toledo, Toledo, Ohio 43606

  • Division of Physical Chemistry, Arrhenius Laboratory, University of Stockholm, S-106 91 Stockholm, Sweden

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Phys. Rev. E 48, 2240 – Published 1 September, 1993

DOI: https://doi.org/10.1103/PhysRevE.48.2240

Abstract

Raman spectroscopy and infrared absorption have been used to study the vibrational dynamics of wet-spun films of the NaDNA-netropsin (NaDNA-net) complex as well as netropsin and NaDNA. The NaDNA-net complex is found to have a substantially different vibrational spectrum from either netropsin or NaDNA. The films of NaDNA-net appear to be more crystalline than the films of NaDNA alone. The formation of the NaDNA-net complex strongly favors the B conformation of the double helix. These vibrational data provide useful information for the understanding of the nature of the interaction of DNA with the antiviral, antitumor antibiotic netropsin.

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Phys. Rev. E 48, 2240– Published 1 September, 1993
  • Received 14 April 1993

© 1993 American Physical Society

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