The annihilation of dark matter into neutrinos over a range of dark matter masses from $\mathrm{MeV}/c^2$ to $\mathrm{ZeV}/c^2$ is reviewed. Thermally produced models of dark matter are expected to self-annihilate to standard model products. As no such signal has yet been detected, neutrino detectors are turned to in order to constrain the “most invisible channel.” The experimental techniques that are used to detect neutrinos are reviewed, and the expected contributions to the neutrino flux at current and upcoming neutrino experiments is revisited. Updated constraints are placed on the dark matter self-annihilation cross section to neutrinos $⟨\sigma v⟩$ using the most recent data, and the sensitivity of upcoming experiments such as Hyper-Kamiokande, Deep Underground Neutrino Experiment (DUNE), and IceCube Gen2 is forecasted. Where possible, limits and projections are scaled to a single set of dark matter halo parameters for consistent comparison. Galactic and extragalactic signals of $s$-, $p$-, and $d$-wave annihilation processes directly into neutrino pairs are considered, yielding constraints that range from $⟨\sigma v⟩\sim 2.5\times {10}^{-26}{\mathrm{cm}}^3{\mathrm{s}}^{-1}$ at $30\mathrm{MeV}/c^2$ to ${10}^{-17}{\mathrm{cm}}^3{\mathrm{s}}^{-1}$ at ${10}^{11}\mathrm{Ge}\mathrm{V}/c^2$. Experiments that report directional and energy information of their events provide much stronger constraints, outlining the importance of making such data public.

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• Extrasolar neutrino astronomy
• Particle dark matter
• Neutrinos
• Neutrino detection