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Colloquium: 100 years of mass spectrometry: Perspectives and future trends

Simon Maher*, Fred P. M. Jjunju, and Stephen Taylor†

Simon Maher*, Fred P. M. Jjunju, and Stephen Taylor†

  • Department of Electrical Engineering and Electronics, University of Liverpool, Liverpool, L69 3GJ, United Kingdom

  • *s.maher@liv.ac.uk
  • †s.taylor@liv.ac.uk
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Rev. Mod. Phys. 87, 113 – Published 28 January, 2015

DOI: https://doi.org/10.1103/RevModPhys.87.113

Abstract

Mass spectrometry (MS) is widely regarded as the most sensitive and specific general purpose analytical technique. More than a century has passed for MS since the ground-breaking work of Nobel laureate Sir Joseph John Thomson in 1913. This Colloquium aims to (1) give an historical overview of the major instrumentation achievements that have driven mass spectrometry forward in the past century, including those leading up to the initial work of Thomson, (2) provide the nonspecialist with an introduction to MS, and (3) highlight some key applications of MS and explore the current and future trends. Because of the vastness of the subject area and quality of the manifold research efforts that have been undertaken over the last 100 years, which have contributed to the foundations and subsequent advances in mass spectrometry, it should be understood that not all of the key contributions may have been included in this Colloquium. Mass spectrometry has embraced a multitude of scientific disciplines and to recognize all of the achievements is an impossible task, such has been the diverse impact of this invaluable technique. Scientific progress is usually made via the cumulative effort of a large number of researchers; the achievements reported herein are only a representation of that effort.

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Rev. Mod. Phys. 87, 113– Published 28 January, 2015
  • Received 25 June 2014

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