In its inaugural year, PRX Life has focused on enhancing the experience of authors and referees working at the intersection of physics and biology. Our goal is to give this interdisciplinary community a voice. Discover what we have accomplished and see what is coming next.

Spontaneous rotations of epithelial spheres reveals chiral tissue patterning mechanisms, showing the interplay between geometry, topology, and collective dynamics.

A novel method to assess protein behavior in extreme environments on the proteome scale shows that proteins with more voids can be more resistant to deformation under high pressure.

Experiments with synthetic droplets in cells, combined with molecular simulations, show the impact of macromolecular crowding and ATP-driven activities on condensate formation.

A theory experimental dialogue offers new insights into the multicomponent depolymerization of actin filaments by profilin, cofilin, and twinfilin.

Adding temporally persistent noise to a polymer model of chromosomes to account for motor-generated active forces captures correlated long-distance motion, dynamic compaction, and other chromosome behaviors.

Opposing flagellar bundles enable bacterial swimming in constrained environments via two novel mechanisms.

Quantitative analysis of the morphological transition in slime mold reveals how this microorganism reorganizes into different shapes, balancing building and transport costs.

Spontaneous rotations of epithelial spheres reveals chiral tissue patterning mechanisms, showing the interplay between geometry, topology, and collective dynamics.

Using a light-controlled robot as a model forager, a first-passage-based framework accurately captures quantitative features of homing, namely the ability for animals to return home from unfamiliar locations, providing a theoretical basis for understanding this ubiquitous behavior.

A model of gene regulation, calibrated on experimental data, proposes that insulator elements weakly bind to chromatin, challenging the previous understanding that insulators only interact with each other when regulating gene activation.

A new method computes the maximization of the capacity for potential actions to influence future states in continuous dynamical systems, linking behavior to fundamental properties for systems of agents autonomously deciding how to act without being given an explicit reward.

A three-photon excited microscopy technique, combined with a multi-element detector and deconvolutional image processing methods, achieves deep imaging of thick biological samples with sub-diffraction-limit resolution better than $\lambda$/8

A novel method to assess protein behavior in extreme environments on the proteome scale shows that proteins with more voids can be more resistant to deformation under high pressure.

A new approach for antibody design uses generative diffusion models to guide the discovery of complementarity-determining regions with properties suitable for therapeutic applications.

By leveraging advances in deep learning this study provides robust and model-free measurements of nonequilibrium and nonlinear behavior in complex living processes.

PolyRep, a 3D polymer model, simulates chromatin replication and reveals how non-specific interactions between chromatin and replisome components influence the dynamics of replication.