The large bending stiffnesses of few-atoms-thick two-dimensional (2D) materials doesn’t allow them to be bent into nanometer-sized tubes or cages. So, different than graphene, most 2D materials don’t have corresponding one-dimensional (1D) nanotube or zero-dimensional (0D) cage structures. In this article, the authors proposed a new strategy to create nanometer-sized 1D or 0D structures of few-atoms-thick 2D materials by using a paper folding-like technique, namely origami approach, to create line defects on one side of the 2D material to induce sharp turns on its surface. Using molybdenum disulfide as an example, their theoretical analysis proved that the origami approach is powerful for creating different types of nanomaterials; some of them are experimentally observed before.