We report a detailed study on the structural, angle-dependent magnetic and magnetotransport properties of highly anisotropic off-stoichiometric CeCuBi2 single crystals. Our results reveal CeCuBi2 as an anisotropic Kondo antiferromagnet exhibiting complex field-induced magnetic behavior and unusual magnetotransport properties. Magnetic susceptibility and specific heat measurements reveal antiferromagnetic (AFM) ordering below TN ∼ 14 K with strong anisotropy and weak heavy-fermion behavior. Electrical transport measurements show highly anisotropic resistivity and a broad hump around ∼ 47 K, indicative of Kondo-driven heavy-fermion behavior. Magnetization measurements reveal multiple field-induced metamagnetic phases, while AC susceptibility measurements indicate slow spin dynamics and spin-glass-like behavior in intermediate field-induced magnetic states. Furthermore, we observe large and strongly anisotropic magnetotransport responses, including room-temperature magnetoresistance of ∼ 22% at 300 K and 9 T and butterfly-like anisotropic magnetoresistance with AMR values reaching ∼ 10.9%. These results highlight a strong interplay among Kondo correlations, magnetic anisotropy, and field-tunable spin configurations, making CeCuBi2 a possible platform for exploring correlated and anisotropic quantum phenomena.