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Optimal Rectification without Forward-Current Suppression by Biological Molecular Motor

Yohei Nakayama and Shoichi Toyabe*

  • Department of Applied Physics, Graduate School of Engineering, Tohoku University, Aoba 6-6-05, Sendai 980-8579, Japan

  • *Corresponding author. toyabe@tohoku.ac.jp
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Phys. Rev. Lett. 126, 208101 – Published 20 May, 2021

DOI: https://doi.org/10.1103/PhysRevLett.126.208101

Abstract

We experimentally show that biological molecular motor F1-ATPase (F1) implements an optimal rectification mechanism. The rectification mechanism hardly suppresses the synthesis of adenosine triphosphate by F1, which is F1’s physiological role, while inhibiting the unfavorable hydrolysis of adenosine triphosphate. This optimal rectification contrasts highly with that of a simple ratchet model, where the inhibition of the backward current is inevitably accompanied by the suppression of the forward current. Our detailed analysis of single-molecule trajectories demonstrates a novel but simple rectification mechanism of F1 with parallel landscapes and asymmetric transition rates.

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Phys. Rev. Lett. 126, 208101– Published 20 May, 2021
  • Received 29 October 2020
  • Accepted 23 April 2021
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