Hemodynamic effects of intra- and supra-deployment locations for a bioprosthetic aortic valve
Martino Andrea Scarpolini, Giovanni Vagnoli, Fabio Guglietta, Roberto Verzicco, and Francesco Viola
Phys. Rev. Fluids 10, 090501 (2025) - Published 18 September, 2025
Choosing the mounting position of an aortic prosthesis—intra- or supra-annular—remains debated, as clinical comparisons rarely isolate hemodynamic effects of valve replacement procedures. We perform fluid-structure interaction simulations of a patient-specific left heart, testing the same bioprosthetic valve in both configurations on the same patient, rationalizing mounting and valve size effects. Supra-annular implantation consistently lowers transvalvular pressure gradients, increases orifice area, and reduces shear and hemolysis risk (see figure). These results provide controlled evidence to guide implantation strategy and device selection in cases of patient-prosthesis mismatch risk.





























































