We show that persistence-based topology of the 21 cm forest encodes information about Cosmic Dawn that is complementary to traditional amplitude- or correlation-based statistics. Applying topological data analysis to simulated one-dimensional forest spectra over a grid of x-ray heating efficiencies $f_X$ and warm-dark-matter (WDM) masses $m_{\mathrm{WDM}}$ (which set the free-streaming scale), we construct persistence diagrams and Betti-0 curves that track the birth-merger hierarchy of absorption troughs under sublevel filtrations. From these summaries, we define three interpretable descriptors: the trough line density $\lambda (t_{\star })$, the total squared persistence $M_2={\sum }_{j\in {\mathcal{I}}_{\mathrm{long}}}{\tau }_j^2$ where ${\mathcal{I}}_{\mathrm{long}}\equiv \{j|{\tau }_j\ge {\tau }_{\star }\}$ denotes long-lived components, and the Betti-curve asymmetry $A_{\mathrm{skew}}$. In a Fisher forecast around a fiducial WDM model, $\lambda (t_{\star })$ and $A_{\mathrm{skew}}$ provide strong local leverage on the heating axis, while $M_2$ retains appreciable sensitivity to the free-streaming scale and supplies an inclined constraint direction that reduces the remaining degeneracy in the $(f_X,m_{\mathrm{WDM}})$ plane. We further demonstrate that, under an SKA1-Low-like uncorrelated thermal-noise model, noise predominantly produces short-lived fluctuations that are removed by imposing the same persistence-lifetime cut ${\tau }_j\ge {\tau }_{\star }$, leaving the topology of long-lived troughs and the gross Betti-curve morphology largely intact. These results establish persistence-based descriptors as a robust non-Gaussian probe of small-scale structure and heating during Cosmic Dawn, naturally complementing power-spectrum and wavelet-based analyses.

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• Cosmology