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Gain-Based Mechanism for pH Sensing Based on Random Lasing

Michele Gaio1,*, Soraya Caixeiro1, Benedetto Marelli2,†, Fiorenzo G. Omenetto2, and Riccardo Sapienza1

  • 1Department of Physics, King’s College London, Strand, London WCR 2LS, United Kingdom
  • 2Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, Massachusetts 02155, USA

  • *michele.gaio@kcl.ac.uk
  • †Present address: Department of Civil and Environmental Engineering, MIT, 77 Massachusetts Avenue, Cambridge, MA 02139-4307, USA.
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Phys. Rev. Applied 7, 034005 – Published 6 March, 2017

DOI: https://doi.org/10.1103/PhysRevApplied.7.034005

Abstract

Here, we investigate the mechanism of a random-lasing-based sensor which shows pH sensitivity exceeding by 2 orders of magnitude that of a conventional fluorescence sensor. We explain the sensing mechanism as related to gain modifications and lasing-threshold nonlinearities. A dispersive diffusive lasing theory matches the experimental results well, and it allows us to predict the optimal sensing conditions and a maximal sensitivity as large as 200 times that of an identical fluorescence-based sensor. The lack of complex alignment and the high sensitivity make this mechanism promising for future biosensing applications.

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Phys. Rev. Applied 7, 034005– Published 6 March, 2017
  • Received 12 August 2016
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Published by the American Physical Society under the terms of the Creative Commons Attribution 4.0 International license. Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI.

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