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Laser-Cooling-Assisted Mass Spectrometry

Christian Schneider*, Steven J. Schowalter, Kuang Chen, Scott T. Sullivan, and Eric R. Hudson

  • Department of Physics and Astronomy, University of California, Los Angeles, California 90095, USA

  • *christian.schneider@physics.ucla.edu
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Phys. Rev. Applied 2, 034013 – Published 30 September, 2014

DOI: https://doi.org/10.1103/PhysRevApplied.2.034013

Abstract

Mass spectrometry is used in a wide range of scientific disciplines including proteomics, pharmaceutics, forensics, and fundamental physics and chemistry. Given this ubiquity, there is a worldwide effort to improve the efficiency and resolution of mass spectrometers. However, the performance of all techniques is ultimately limited by the initial phase-space distribution of the molecules being analyzed. Here, we dramatically reduce the width of this initial phase-space distribution by sympathetically cooling the input molecules with laser-cooled, cotrapped atomic ions, improving both the mass resolution and detection efficiency of a time-of-flight mass spectrometer by over an order of magnitude. Detailed molecular-dynamics simulations verify the technique and aid with evaluating its effectiveness. This technique appears to be applicable to other types of mass spectrometers.

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Synopsis

Slow Down to Take a Better Spectrum

Published 30 September, 2014

The resolution and sensitivity of mass spectrometers can be improved by laser-cooling the measured sample species.

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Article Text

References (62)

  1. J. R. Yates III, A century of mass spectrometry: From atoms to proteomes, Nat. Methods 8, 633 (2011).
  2. Mass Spectrometry: Limitless Innovation in Analytical Science. Market Forecast: 2013–2017 (table of contents) (Strategic Directions International, Inc., 2012).
  3. S. Dresen, S. Kneisel, W. Weinmann, R. Zimmermann, and V. Auwärter, Development and validation of a liquid chromatography-tandem mass spectrometry method for the quantitation of synthetic cannabinoids of the aminoalkylindole type and methanandamide in serum and its application to forensic samples, J. Mass Spectrom. 46, 163 (2011).
  4. M. Hermanns-Clausen, S. Kneisel, B. Szabo, and V. Auwärter, Acute toxicity due to the confirmed consumption of synthetic cannabinoids: Clinical and laboratory findings, Addiction 108, 534 (2013).
  5. B. F. Cravatt, G. M. Simon, and J. R. Yates III, The biological impact of mass-spectrometry-based proteomics, Nature (London) 450, 991 (2007).
  6. S. A. Hofstadler and K. A. Sannes-Lowery, Applications of ESI-MS in drug discovery: Interrogation of noncovalent complexes, Nat. Rev. Drug Discovery 5, 585 (2006).
  7. H.-J. Kluge, High-accuracy mass spectrometry for fundamental studies, Eur. J. Mass Spectrom. 16, 269 (2010).
  8. W. C. Wiley and I. H. McLaren, Time-of-flight mass spectrometer with improved resolution, Rev. Sci. Instrum. 26, 1150 (1955).
  9. M. B. Comisarow and A. G. Marshall, Fourier transform ion cyclotron resonance spectroscopy, Chem. Phys. Lett. 25, 282 (1974).
  10. B. A. Mamyrin, V. I. Karataev, D. V. Shmikk, and V. A. Zagulin, The mass-reflectron, a new nonmagnetic time-of-flight mass spectrometer with high resolution, Sov. Phys. JETP 37, 45 (1973) [Zh. Eksp. Teor. Fiz. 64, 82 (1973)].
  11. J. H. J. Dawson and M. Guilhaus, Orthogonal-acceleration time-of-flight mass spectrometer, Rapid Commun. Mass Spectrom. 3, 155 (1989).
  12. Q. Hu, R. J. Noll, H. Li, A. Makarov, M. Hardman, and R. Graham Cooks, The Orbitrap: A new mass spectrometer, J. Mass Spectrom. 40, 430 (2005).
  13. M. Yamashita and J. B. Fenn, Electrospray ion source. Another variation on the free-jet theme, J. Phys. Chem. 88, 4451 (1984).
  14. J. B. Fenn, M. Mann, C. K. Meng, S. F. Wong, and C. M. Whitehouse, Electrospray ionization for mass spectrometry of large biomolecules, Science 246, 64 (1989).
  15. M. Karas, D. Bachmann, and F. Hillenkamp, Influence of the wavelength in high-irradiance ultraviolet laser desorption mass spectrometry of organic molecules, Anal. Chem. 57, 2935 (1985).
  16. K. Tanaka, H. Waki, Y. Ido, S. Akita, Y. Yoshida, T. Yoshida, and T. Matsuo, Protein and polymer analyses up to m/z 100 000 by laser ionization time-of-flight mass spectrometry, Rapid Commun. Mass Spectrom. 2, 151 (1988).
  17. F. Hillenkamp, M. Karas, R. C. Beavis, and B. T. Chait, Matrix-assisted laser desorption/ionization mass spectrometry of biopolymers, Anal. Chem. 63, 1193A (1991).
  18. L. Schweikhard, S. Guan, and A. G. Marshall, Quadrupolar excitation and collisional cooling for axialization and high pressure trapping of ions in Fourier transform ion cyclotron resonance mass spectrometry, Int. J. Mass Spectrom. Ion Process. 120, 71 (1992).
  19. J. W. Hager, A new linear ion trap mass spectrometer, Rapid Commun. Mass Spectrom. 16, 512 (2002).
  20. I. V. Chernushevich and B. A. Thomson, Collisional cooling of large ions in electrospray mass spectrometry, Anal. Chem. 76, 1754 (2004).
  21. A. N. Krutchinsky, A. V. Loboda, V. L. Spicer, R. Dworschak, W. Ens, and K. G. Standing, Orthogonal injection of matrix-assisted laser desorption/ionization ions into a time-of-flight spectrometer through a collisional damping interface, Rapid Commun. Mass Spectrom. 12, 508 (1998).
  22. A. V. Loboda, S. Ackloo, and I. V. Chernushevich, A high-performance matrix-assisted laser desorption/ionization orthogonal time-of-flight mass spectrometer with collisional cooling, Rapid Commun. Mass Spectrom. 17, 2508 (2003).
  23. A. Makarov, E. Denisov, A. Kholomeev, W. Balschun, O. Lange, K. Strupat, and S. Horning, Performance evaluation of a hybrid linear ion trap/orbitrap mass spectrometer, Anal. Chem. 78, 2113 (2006).
  24. D. Douglas and J. French, Collisional focusing effects in radio frequency quadrupoles, J. Am. Soc. Mass Spectrom. 3, 398 (1992).
  25. D. J. Larson, J. C. Bergquist, J. J. Bollinger, W. M. Itano, and D. J. Wineland, Sympathetic cooling of trapped ions: A laser-cooled two-species nonneutral ion plasma, Phys. Rev. Lett. 57, 70 (1986).
  26. T. Baba and I. Waki, Cooling and mass-analysis of molecules using laser-cooled atoms, Jpn. J. Appl. Phys. 35, L1134 (1996).
  27. M. Bussmann, U. Schramm, D. Habs, V. Kolhinen, and J. Szerypo, Stopping highly charged ions in a laser-cooled one component plasma of ions, Int. J. Mass Spectrom. 251, 179 (2006).
  28. R. Cazan, C. Geppert, W. Nörtershäuser, and R. Sánchez, Towards sympathetic cooling of trapped ions with laser-cooled Mg+ ions for mass spectrometry and laser spectroscopy, Hyperfine Interact. 196, 177 (2010).
  29. Z. Andelkovic, R. Cazan, W. Nörtershäuser, S. Bharadia, D. M. Segal, R. C. Thompson, R. Jöhren, J. Vollbrecht, V. Hannen, and M. Vogel, Laser cooling of externally produced Mg ions in a Penning trap for sympathetic cooling of highly charged ions, Phys. Rev. A 87, 033423 (2013).
  30. A. Ostendorf, C. B. Zhang, M. A. Wilson, D. Offenberg, B. Roth, and S. Schiller, Sympathetic cooling of complex molecular ions to millikelvin temperatures, Phys. Rev. Lett. 97, 243005 (2006).
  31. D. Offenberg, C. B. Zhang, C. Wellers, B. Roth, and S. Schiller, Translational cooling and storage of protonated proteins in an ion trap at subkelvin temperatures, Phys. Rev. A 78, 061401 (2008).
  32. S. J. Schowalter, K. Chen, W. G. Rellergert, S. T. Sullivan, and E. R. Hudson, An integrated ion trap and time-of-flight mass spectrometer for chemical and photo-reaction dynamics studies, Rev. Sci. Instrum. 83, 043103 (2012).
  33. D. J. Berkeland and M. G. Boshier, Destabilization of dark states and optical spectroscopy in Zeeman-degenerate atomic systems, Phys. Rev. A 65, 033413 (2002).
  34. C. L. Jolliffe, Mass spectrometer with radial ejection, U.S. Patent No. 5,576,540 (19 November 1996) (see http://www.freepatentsonline.com/5576540.html).
  35. J. Franzen, Method and device for orthogonal ion injection into a time-of-flight mass spectrometer, U.S. Patent No. 5,763,878 (9 June 1998) (see http://www.freepatentsonline.com/5763878.html).
  36. G. Audi and A. Wapstra, The 1995 update to the atomic mass evaluation, Nucl. Phys. A595, 409 (1995).
  37. A. A. Sonzogni, NuDat 2.0: Nuclear structure and decay data on the internet, AIP Conf. Proc. 769, 574 (2005).
  38. T. Matthey, T. Cickovski, S. Hampton, A. Ko, Q. Ma, M. Nyerges, T. Raeder, T. Slabach, and J. A. Izaguirre, ProtoMol, an object-oriented framework for prototyping novel algorithms for molecular dynamics, ACM Trans. Math. Softw. 30, 237 (2004).
  39. C. Rosales Fernández, depSolver v2.1 (Institute of High Performance Computing, Singapore, 2008).
  40. S. Schiller and C. Lämmerzahl, Molecular dynamics simulation of sympathetic crystallization of molecular ions, Phys. Rev. A 68, 053406 (2003).
  41. T. Baba and I. Waki, Sympathetic cooling rate of gas-phase ions in a radio-frequency-quadrupole ion trap, Appl. Phys. B 74, 375 (2002).
  42. K. Chen, S. T. Sullivan, and E. R. Hudson, Neutral gas sympathetic cooling of an ion in a Paul trap, Phys. Rev. Lett. 112, 143009 (2014).
  43. P. Blythe, B. Roth, U. Fröhlich, H. Wenz, and S. Schiller, Production of ultracold trapped molecular hydrogen ions, Phys. Rev. Lett. 95, 183002 (2005).
  44. D. Trypogeorgos and C. J. Foot, A two-frequency ion trap confining ions with widely different charge-to-mass ratios, arXiv:1310.6294.
  45. K. Jungmann, J. Hoffnagle, R. G. DeVoe, and R. G. Brewer, Collective oscillations of stored ions, Phys. Rev. A 36, 3451 (1987).
  46. G. Birkl, S. Kassner, and H. Walther, Multiple-shell structures of laser-cooled  Mg24+ ions in a quadrupole storage ring, Nature (London) 357, 310 (1992).
  47. C. B. Zhang, D. Offenberg, B. Roth, M. A. Wilson, and S. Schiller, Molecular-dynamics simulations of cold single-species and multispecies ion ensembles in a linear Paul trap, Phys. Rev. A 76, 012719 (2007).
  48. P. F. Staanum, K. Højbjerre, P. S. Skyt, A. K. Hansen, and M. Drewsen, Rotational laser cooling of vibrationally and translationally cold molecular ions, Nat. Phys. 6, 271 (2010).
  49. S. Kahra, G. Leschhorn, M. Kowalewski, A. Schiffrin, E. Bothschafter, W. Fuß, R. de Vivie-Riedle, R. Ernstorfer, F. Krausz, R. Kienberger, and T. Schaetz, A molecular conveyor belt by controlled delivery of single molecules into ultrashort laser pulses, Nat. Phys. 8, 238 (2012).
  50. Y.-P. Chang, K. Długołęcki, J. Küpper, D. Rösch, D. Wild, and S. Willitsch, Specific chemical reactivities of spatially separated 3-aminophenol conformers with cold Ca+ ions, Science 342, 98 (2013).
  51. M. Drewsen, A. Mortensen, R. Martinussen, P. Staanum, and J. L. Sørensen, Nondestructive identification of cold and extremely localized single molecular ions, Phys. Rev. Lett. 93, 243201 (2004).
  52. K. Chen, S. J. Schowalter, S. Kotochigova, A. Petrov, W. G. Rellergert, S. T. Sullivan, and E. R. Hudson, Molecular-ion trap-depletion spectroscopy of BaCl+, Phys. Rev. A 83, 030501 (2011).
  53. K.-K. Ni, H. Loh, M. Grau, K. C. Cossel, J. Ye, and E. A. Cornell, State-specific detection of trapped HfF+ by photodissociation, arXiv:1401.5423v1.
  54. C. M. Seck, E. G. Hohenstein, C.-Y. Lien, P. R. Stollenwerk, and B. C. Odom, Rotational state analysis of AlH+ by two-photon dissociation, J. Mol. Spectrosc. 300, 108 (2014).
  55. P. Puri, S. J. Schowalter, S. Kotochigova, A. Petrov, and E. R. Hudson, Action spectroscopy of SrCl+ using an integrated ion trap time-of-flight mass spectrometer, J. Chem. Phys. 141, 014309 (2014).
  56. A. Härter and J. Hecker Denschlag, Cold atom-ion experiments in hybrid traps, Contemp. Phys. 55, 33 (2014).
  57. S. Willitsch, Ion-atom hybrid systems, arXiv:1401.1699v1.
  58. C. Sias and M. Köhl, Hybrid quantum systems of ions and atoms, arXiv:1401.3188v1.
  59. W. G. Rellergert, S. T. Sullivan, S. Kotochigova, A. Petrov, K. Chen, S. J. Schowalter, and E. R. Hudson, Measurement of a large chemical reaction rate between ultracold closed-shell Ca40 atoms and open-shell Yb174+ ions held in a hybrid atom-ion trap, Phys. Rev. Lett. 107, 243201 (2011).
  60. S. T. Sullivan, W. G. Rellergert, S. Kotochigova, and E. R. Hudson, Role of electronic excitations in ground-state-forbidden inelastic collisions between ultracold atoms and ions, Phys. Rev. Lett. 109, 223002 (2012).
  61. S. T. Sullivan, W. G. Rellergert, S. Kotochigova, K. Chen, S. J. Schowalter, and E. R. Hudson, Trapping molecular ions formed via photo-associative ionization of ultracold atoms, Phys. Chem. Chem. Phys. 13, 18859 (2011).
  62. W. G. Rellergert, S. T. Sullivan, S. J. Schowalter, S. Kotochigova, K. Chen, and E. R. Hudson, Evidence for sympathetic vibrational cooling of translationally cold molecules, Nature (London) 495, 490 (2013).

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Phys. Rev. Applied 2, 034013– Published 30 September, 2014
  • Received 15 April 2014

© 2014 American Physical Society

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