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Band Alignment Engineers Faradaic and Capacitive Photostimulation of Neurons Without Surface Modification

Shashi Bhushan Srivastava1, Rustamzhon Melikov1, Mohammad Mohammadi Aria2, Ugur Meric Dikbas3, Ibrahim Halil Kavakli3,4, and Sedat Nizamoglu1,2,*

  • 1Department of Electrical and Electronics Engineering, Koc University, Istanbul 34450, Turkey
  • 2Graduate School of Biomedical Sciences and Engineering, Koc University, Istanbul 34450, Turkey
  • 3Molecular Biology and Genetics, College of Science, Koc University, Istanbul 34450, Turkey
  • 4College of Engineering, Chemical and Biological Engineering, Koç University, Istanbul 34450, Turkey

  • *snizamoglu@ku.edu.tr
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Phys. Rev. Applied 11, 044012 – Published 4 April, 2019

DOI: https://doi.org/10.1103/PhysRevApplied.11.044012

Abstract

Photovoltaic substrates have attracted significant attention for neural photostimulation. The control of the Faradaic and capacitive (non-Faradaic) charge transfer mechanisms by these substrates are critical for safe and effective neural photostimulation. We demonstrate that the intermediate layer can directly control the strength of the capacitive and Faradaic processes under physiological conditions. To resolve the Faradaic and capacitive stimulations, we enhance photogenerated charge density levels by incorporating PbS quantum dots into a poly(3-hexylthiophene-2,5-diyl):([6,6]-Phenyl-C61-butyric acid methyl ester (P3HT:PCBM) blend. This enhancement stems from the simultaneous increase of absorption, well matched band alignment of PbS quantum dots with P3HT:PCBM, and smaller intermixed phase-separated domains with better homogeneity and roughness of the blend. These improvements lead to the photostimulation of neurons at a low light intensity level of 1 mW cm−2, which is within the retinal irradiance level. These findings open up an alternative approach toward superior neural prosthesis.

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Corrections

17 June, 2019

Correction: The surname of the eighth author contained a typographical error and has been fixed. A reference and its citation in Appendix B 2 were missing and have been inserted.

Article Text

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Outline

Information

Phys. Rev. Applied 11, 044012– Published 4 April, 2019
  • Received 1 November 2018
  • Revised 20 February 2019
  • Corrected 17 June 2019
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